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By activating GLP-1 receptors in the brain, semaglutide GLP-1 helps you feel fuller for longer periods, reducing cravings and overeating

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Amitriptyline also has anticholinergic properties that can slow the digestive system, with constipation listed as a very common side effect

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However, a more detailed evaluation of inflammatory cells and activity in tissues or epithelial brushings is needed before their contribution can be ruled out